بسم الله الرحمن الرحيم
Pseudomonas aeruginosa
The antibiotics used for treatment of P. aeruginosa infection are:
1- Ceftazidime
2- Gentamicin or Tobramycin
3- Piperacillin
4- Amikacin
5- Aztreonam
6- Cefepime
7- Ciprofloxacin
8- Levofloxacin
9- Imipenem or Meropenem
10- Piperacillin – tazobactam
11- Ticarcillin
For urinary tract infection:
1- Lomefloxacin or Ofloxacin
2- Norfloxacin
The percentage of resistant P. aeruginosa isolated in medical – city –central – teaching – laboratory to antibiotics (from July 1st to December 28th 2009)
13% Imipenem
33% Amikacin
55% Gentamicin
19% Ciprofloxacin
39% Piperacillin
88% Cefepime
P. aeruginosa may develop resistance during prolonged therapy with all antibiotics. Therefore isolates that are initially susceptible may become resistant within three to four days after initiation of therapy.
P. aeruginosa is intrinsically resistant to first and second generation cephalosporins, amino penicillin and amino penicillin, β-lactamase inhibitor combination.
P. aeruginosa is also intrinsically resistant to kanamycin; primary quinolones, Chloramphenicol, tetracycline, Trimethoprime and Trimethoprime- Sulphamethoxazole.
Cefotaxime, Ceftizoxime, Ceftriaxone, Moxalactam [an oxaephem] lack activity against P.aeruginosa
P aeruginosa in granulocytopic patients and serious infections in other patients should be treated with maximum doses of the selected antipsedomonal / penicillin [carboxy- penicillin or ureidopenicillin] or Ceftazidime in combination with an amino glycoside.